Total Synthesis of Syringolin A

被引：40

作者：

Dai, Chunhui ^{[1
]}

Stephenson, Corey R. J. ^{[1
]}

机构：

[1] Boston Univ, Dept Chem, Boston, MA 02215 USA

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 15期

关键词：

PROTEASOME INHIBITION; PV; SYRINGAE; PROTEIN-DEGRADATION; MULTIPLE-MYELOMA; CANCER; ELICITOR; THERAPY; TARGET; RICE;

D O I：

10.1021/ol101252y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convergent, efficient synthesis of syringolin A has been accomplished in 13 steps from commercially available materials, Garner's aldehyde and L-valine. The unnatural 3,4-dehydrolysine fragment was prepared using successive Johnson-Claisen/Curtius rearrangement reactions. The macrolactamization and late-stage introduction of the side chain will provide convenient access to analogues of this promising proteasome Inhibitor.

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收藏

页码：3453 / 3455

页数：3

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