A facile synthesis of perfluoroalkyl vinyl iodides and their palladium-mediated cross-coupling reactions

被引：75

作者：

Jennings, MP ^{[1
]}

Cork, EA ^{[1
]}

Ramachandran, PV ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, Herbert C Brown Ctr Borane Res, W Lafayette, IN 47907 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2000年 / 65卷 / 25期

关键词：

D O I：

10.1021/jo001318c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Catalytic amounts of zinc, as low as 10 mol %, in the presence of trifluoroacetic acid (TFA) initiate the radical addition of perfluoroalkyl iodides to terminal alkynes with high regio- and stereoselectivities. Palladium-mediated cross-coupling of these (E)-perfluoroalkyl vinyl iodides allows for a. facile synthesis of potentially useful fluoroorganic intermediates.

引用

页码：8763 / 8766

页数：4

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