N-methylsansalvamide, a cytotoxic cyclic depsipeptide from a marine fungus of the genus Fusarium

被引：60

作者：

Cueto, M ^{[1
]}

Jensen, PR ^{[1
]}

Fenical, W ^{[1
]}

机构：

[1] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA

来源：

PHYTOCHEMISTRY | 2000年 / 55卷 / 03期

关键词：

Fusarium sp; marine fungi; cyclic depsipeptide;

D O I：

10.1016/S0031-9422(00)00280-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

N-Methylsansalvamide (1), a new cyclic depsipeptide. was isolated from extracts of a cultured marine fungus, strain CNL-619, identified as a member of the genus Fusarium. N-Methylsansalvamide exhibits weak in vitro cytotoxicity in the NCI human tumor cell line screen (GI(50) 8.3 muM). The structure of 1 was determined by combined spectral and chemical methods. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：223 / 226

页数：4

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