Nonsense-mediated mRNA decay in Saccharomyces cerevisiae:: A quality control mechanism that degrades transcripts harboring premature termination codons

被引:15
作者
González, CI
Wang, W
Peltz, SW
机构
[1] Univ Puerto Rico, Dept Biol, San Juan, PR 00931 USA
[2] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Mol Genet & Microbiol, Piscataway, NJ 08854 USA
[3] PTC Therapeut, S Plainfield, NJ 07080 USA
[4] Canc Inst New Jersey, Piscataway, NJ 08854 USA
关键词
D O I
10.1101/sqb.2001.66.321
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:321 / 328
页数:8
相关论文
共 87 条
[1]   SELECTIVE DESTABILIZATION OF SHORT-LIVED MESSENGER-RNAS WITH THE GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR AU-RICH 3' NONCODING REGION IS MEDIATED BY A COTRANSLATIONAL MECHANISM [J].
AHARON, T ;
SCHNEIDER, RJ .
MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (03) :1971-1980
[2]   The 3′ to 5′ degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3′ to 5′ exonucleases of the exosome complex [J].
Anderson, JSJ ;
Parker, R .
EMBO JOURNAL, 1998, 17 (05) :1497-1506
[3]   Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein [J].
Applequist, SE ;
Selg, M ;
Raman, C ;
Jack, HM .
NUCLEIC ACIDS RESEARCH, 1997, 25 (04) :814-821
[4]  
BEELMAN CA, 1994, J BIOL CHEM, V269, P9687
[5]   An essential component of the decapping enzyme required for normal rates of mRNA turnover [J].
Beelman, CA ;
Stevens, A ;
Caponigro, G ;
LaGrandeur, TE ;
Hatfield, L ;
Fortner, DM ;
Parker, R .
NATURE, 1996, 382 (6592) :642-646
[6]   Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay [J].
Bhattacharya, A ;
Czaplinski, K ;
Trifillis, P ;
He, F ;
Jacobson, A ;
Peltz, SW .
RNA, 2000, 6 (09) :1226-1235
[7]   The yeast Pan2 protein is required for poly(A)-binding protein-stimulated poly(A)-nuclease activity [J].
Boeck, R ;
Tarun, S ;
Rieger, M ;
Deardorff, JA ;
MullerAuer, S ;
Sachs, AB .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (01) :432-438
[8]   The two proteins Pat1p (Mrt1p) and Spb8p interact in vivo, are required for mRNA decay, and are functionally linked to Pab1p [J].
Bonnerot, C ;
Boeck, R ;
Lapeyre, B .
MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (16) :5939-5946
[9]   A Sm-like protein complex that participates in mRNA degradation [J].
Bouveret, E ;
Rigaut, G ;
Shevchenko, A ;
Wilm, M ;
Séraphin, B .
EMBO JOURNAL, 2000, 19 (07) :1661-1671
[10]   SEQUENCE-SPECIFIC ENDONUCLEOLYTIC CLEAVAGE AND PROTECTION OF MESSENGER-RNA IN XENOPUS AND DROSOPHILA [J].
BROWN, BD ;
ZIPKIN, ID ;
HARLAND, RM .
GENES & DEVELOPMENT, 1993, 7 (08) :1620-1631