Conjugate addition of amino acid side chains to dyes containing alkynone, alkynoic ester and alkynoic amide linker arms

被引：9

作者：

Crisp, GT ^{[1
]}

Millan, MJ ^{[1
]}

机构：

[1] Univ Adelaide, Dept Chem, Adelaide, SA 5005, Australia

来源：

TETRAHEDRON | 1998年 / 54卷 / 3-4期

关键词：

D O I：

10.1016/S0040-4020(97)10324-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Derivatives of fluorescein, 7-hydroxycoumarin, Sudan 1 and dansyl chloride with linker arms containing a conjugated terminal alkyne have been prepared. The Michael addition of the sulfanyl group of protected cysteine, the hydroxyl group of protected serine and the E-amino group of protected lysine to the conjugated alkyne gave the expected heterosubstituted vinyl producs. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：649 / 666

页数：18

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