Vitamin E isoforms α-tocotrienol and γ-tocopherol prevent cerebral infarction in mice

被引：79

作者：

Mishima, K

Tanaka, T

Pu, FL

Egashira, N

Iwasaki, K

Hidaka, R

Matsunaga, K

Takata, J

Karube, Y

Fujiwara, M ^{[1
]}

机构：

[1] Fukuoka Univ, Fac Pharmaceut Sci, Dept Neuropharmacol, Fukuoka 8140180, Japan

[2] Fukuoka Univ, Adv Mat Inst, Fukuoka 8140180, Japan

[3] Fukuoka Univ, Fac Pharmaceut Sci, Lab Drug Design & Drug Delivery, Fukuoka 8140180, Japan

来源：

NEUROSCIENCE LETTERS | 2003年 / 337卷 / 01期

关键词：

vitamin E; alpha-tocopherol; alpha-tocotrienol; gamma-tocopherol; cerebral ischemia;

D O I：

10.1016/S0304-3940(02)01293-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

alpha-tocopherol and its derivatives have been shown to be effective in reducing cerebral ischemia-induced brain damage. However, the effects of other vitamin E isoforms have not been characterized. In the present study, we investigated the effects of six different isoforms of vitamin E on the ischemic brain damage in the mice middle cerebral artery (MCA) occlusion model. All vitamin E isoforms were injected i.v., twice, immediately before and 3 h after the occlusion. alpha-tocopherol (2 mM), alpha-tocotrienol (0.2 and 2 mM) and gamma-tocopherol (0.2 and 2 mM) significantly decreased the size of the cerebral infarcts 1 day after the MCA occlusion, while gamma-tocotrienol, delta-tocopherol and delta-tocotrienol showed no effect on the cerebral infarcts. These results suggest that a-tocotrienol and gamma-tocopherol are potent and effective agents for preventing cerebral infarction induced by MCA occlusion. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：56 / 60

页数：5

共 23 条

[1] Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice [J].