Molecular imaging, targeted therapeutics, and nanoscience

被引:65
作者
Wickline, SA
Lanza, GM
机构
[1] Washington Univ, Sch Med, St Louis, MO 63110 USA
[2] Barnes Jewish Hosp, Dept Med, St Louis, MO 63110 USA
[3] Barnes Jewish Hosp, Dept Biomed Engn, St Louis, MO 63110 USA
[4] Barnes Jewish Hosp, Dept Phys, St Louis, MO 63110 USA
关键词
molecular imaging; nanotechnology; magnetic resonance imaging;
D O I
10.1002/jcb.10422
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The recent emergence of "molecular imaging" as an academic discipline has set the stage for an evolutionary leap in diagnostic imaging. Recent advances in nuclear, ultrasound, optical, and magnetic resonance imaging have generated interest in molecular imaging across all modalities and across various academic, industrial, and governmental agencies. In this perspective, examples of the progress and the prospects for the future of molecular imaging and linked targeted therapeutics are reviewed.
引用
收藏
页码:90 / 97
页数:8
相关论文
共 38 条
[1]   In vivo imaging of gene and cell therapies [J].
Allport, JR ;
Weissleder, R .
EXPERIMENTAL HEMATOLOGY, 2001, 29 (11) :1237-1246
[2]  
Anderson SA, 2000, MAGNET RESON MED, V44, P433, DOI 10.1002/1522-2594(200009)44:3<433::AID-MRM14>3.0.CO
[3]  
2-9
[4]   Uptake of radiolabeled 2′-fluoro-2′-deoxy-5-iodo-1-β-D-arabinofuranosyluracil in cardiac cells after adenoviral transfer of the herpesvirus thymidine kinase gene -: The cellular basis for cardiac gene imaging [J].
Bengel, FM ;
Anton, M ;
Avril, N ;
Brill, T ;
Nguyen, N ;
Haubner, R ;
Gleiter, E ;
Gansbacher, B ;
Schwaiger, M .
CIRCULATION, 2000, 102 (09) :948-950
[5]   In vivo detection and imaging of phosphatidylserine expression during programmed cell death [J].
Blankenberg, FG ;
Katsikis, PD ;
Tait, JF ;
Davis, RE ;
Naumovski, L ;
Ohtsuki, K ;
Kopiwoda, S ;
Abrams, MJ ;
Darkes, M ;
Robbins, RC ;
Maecker, HT ;
Strauss, HW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (11) :6349-6354
[6]   Approaches and agents for imaging the vascular system [J].
Bogdanov, AA ;
Lewin, M ;
Weissleder, R .
ADVANCED DRUG DELIVERY REVIEWS, 1999, 37 (1-3) :279-293
[7]  
Bryant LH, 1999, JMRI-J MAGN RESON IM, V9, P348, DOI 10.1002/(SICI)1522-2586(199902)9:2<348::AID-JMRI30>3.0.CO
[8]  
2-J
[9]  
BULTE JW, 2001, MOL IMAGING, V1, P225
[10]   Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells [J].
Bulte, JWM ;
Douglas, T ;
Witwer, B ;
Zhang, SC ;
Strable, E ;
Lewis, BK ;
Zywicke, H ;
Miller, B ;
van Gelderen, P ;
Moskowitz, BM ;
Duncan, ID ;
Frank, JA .
NATURE BIOTECHNOLOGY, 2001, 19 (12) :1141-1147