A new polymer-supported reagent for the synthesis of β-lactams in solution

被引：32

作者：

Donati, D

Morelli, C

Porcheddu, A

Taddei, M

机构：

[1] Univ Sassari, Dipartimento Chim, I-07100 Sassari, Italy

[2] Univ Siena, Dipartimento Chim, I-53100 Siena, Italy

[3] Univ Siena, Dipartimento Farmaco Chim Tecnol, I-53100 Siena, Italy

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 69卷 / 26期

关键词：

D O I：

10.1021/jo048400i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A modified Mukaiyama reagent was prepared on a PS-DVB resin. This reagent was used for the preparation of beta-lactams, using the Staudinger reaction. The products were obtained by generating the ketene from a carboxylic acid under sonication with the resin followed by reaction with the imine. Excess of the imine was removed by reduction followed by acid scavenging.

引用

页码：9316 / 9318

页数：3

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