Intelligence and event-related potentials for young female human volunteer apolipoprotein E ε4 and non-ε4 carriers

被引：74

作者：

Yu, VWY

Lin, CH

Chen, SP

Hong, CJ

Tsai, SJ ^{[1
]}

机构：

[1] Yus Psychiat Clin, Kaohsiung, Taiwan

[2] Kai Suan Psychiat Hosp, Kaohsiung, Taiwan

[3] Natl Yang Ming Univ, Sch Med, Div Psychiat, Taipei 112, Taiwan

[4] Vet Gen Hosp, Dept Psychiat, Taipei 11217, Taiwan

来源：

NEUROSCIENCE LETTERS | 2000年 / 294卷 / 03期

关键词：

event-related potentials; apolipoprotein E; intelligence; female;

D O I：

10.1016/S0304-3940(00)01569-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The apolipoprotein E (APOE) epsilon4 allel is associated with late-onset Alzheimer's disease and cognitive function in aging normal populations. To study the effect of the presence of the epsilon4 allele on cognitive function, we compared intelligence-test scores and component values for event-related potentials for epsilon4 and non-epsilon4 carriers in a group of 134 young females. The results demonstrate modest increases in performance intelligence quotient (IQ) and N100 amplitude for epsilon4 carriers (P = 0.038 and 0.068, respectively). Our findings suggest that cognitive impairment, associated with the presence of the epsilon4 allele, is age-dependent and thus not probable for young women. The higher performance IQ scores demonstrated for epsilon4 carriers require further exploration. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

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收藏

页码：179 / 181

页数：3

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