Differential effects of cholesterol and oxidised-cholesterol in egg lecithin bilayers

被引：59

作者：

Karolis, C

Coster, HGL ^{[1
]}

Chilcott, TC

Barrow, KD

机构：

[1] Univ New S Wales, UNESCO, Ctr Membrane Sci & Technol, Sydney, NSW 2052, Australia

[2] Univ New S Wales, Sch Phys, Dept Biophys, Sydney, NSW 2052, Australia

[3] Univ New S Wales, Sch Biochem & Mol Genet, Sydney, NSW 2052, Australia

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1998年 / 1368卷 / 02期

关键词：

cholesterol; lecithin; bilayer;

D O I：

10.1016/S0005-2736(97)00180-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Low frequency impedance measurements of pure egg lecithin (phosphatidylcholine) bilayers have revealed the presence of four layers which can be attributed to the acyl chain, carbonyl, glycerol bridge and phosphatidylcholine regions of the lecithin molecule. Measurements on bilayers formed in the presence of unoxidised-cholesterol revealed that cholesterol molecules were located in the hydrocarbon region of the bilayer with its hydroxyl groups aligned with the carbonyl region of the lecithin molecules. Measurements of oxidised-cholesterol lecithin bilayers revealed that these molecules protruded less into the hydrocarbon region and their polar hydroxyl group aligned with the glycerol bridge region of the lecithin molecule. (C) 1998 Elsevier Science B.V.

引用

页码：247 / 255

页数：9

共 44 条

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