Plasma insulin-like growth factor I and prostate cancer risk: A prospective study

被引：1631

作者：

Chan, JM

Stampfer, MJ

Giovannucci, E

Gann, PH

Ma, J

Wilkinson, P

Hennekens, CH

Pollak, M

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Channing Lab, Boston, MA 02115 USA

[3] Northwestern Univ, Sch Med, Dept Prevent Med, Chicago, IL 60611 USA

[4] McGill Univ, Jewish Gen Hosp, Lady Davis Inst Med Res, Dept Med,Canc Prevent Res Unit, Montreal, PQ H3T 1E2, Canada

[5] McGill Univ, Jewish Gen Hosp, Lady Davis Inst Med Res, Dept Oncol,Canc Prevent Res Unit, Montreal, PQ H3T 1E2, Canada

[6] Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02115 USA

[7] Brigham & Womens Hosp, Dept Ambulatory Care & Prevent, Boston, MA 02115 USA

[8] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

SCIENCE | 1998年 / 279卷 / 5350期

关键词：

D O I：

10.1126/science.279.5350.563

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Insulin-like growth factor-I (IGF-I) is a mitogen for prostate epithelial cells. To investigate associations between plasma IGF levels and prostate cancer risk, a nested case-control study within the Physicians' Health Study was conducted on prospectively collected plasma from 152 cases and 152 controls. A strong positive association was observed between IGF-I levels and prostate cancer risk. Men in the highest quartile of IGF-I levels had a relative risk of 4.3 (95 percent confidence interval 1.8 to 10.6) compared with men in the lowest quartile. This association was independent of baseline prostate-specific antigen levels. Identification of plasma IGF-I as a predictor of prostate cancer risk may have implications for risk reduction and treatment.

引用

页码：563 / 566

页数：4

共 28 条

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