Targeting metabolic transformation for cancer therapy

被引：906

作者：

Tennant, Daniel A. ^{[1
]}

Duran, Raul V. ^{[2
]}

Gottlieb, Eyal ^{[1
]}

机构：

[1] Beatson Inst Canc Res, Canc Res UK, Glasgow G61 1BD, Lanark, Scotland

[2] Univ Basel, Growth & Dev Biozentrum, Basel, Switzerland

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 04期

关键词：

FATTY-ACID SYNTHASE; TUMOR-CELL GROWTH; RECURRENT GLIOBLASTOMA-MULTIFORME; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; CARBONIC-ANHYDRASE INHIBITORS; BREAST-CARCINOMA CELLS; PHASE-II TRIAL; PYRUVATE-KINASE; TEMSIROLIMUS CCI-779; KETOGENIC DIET;

D O I：

10.1038/nrc2817

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer therapy has long relied on the rapid proliferation of tumour cells for effective treatment. However, the lack of specificity in this approach often leads to undesirable side effects. Many reports have described various 'metabolic transformation' events that enable cancer cells to survive, suggesting that metabolic pathways might be good targets. There are currently several drugs under development or in clinical trials that are based on specifically targeting the altered metabolic pathways of tumours. This Review highlights pathways against which there are already drugs in different stages of development and also discusses additional druggable targets.

引用

页码：267 / 277

页数：11

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