Reference materials for the evaluation of pre-mortem variant Creutzfeldt-Jakob disease diagnostic assays

被引：8

作者：

Cooper, J. K. ^{[1
]}

Ladhani, K. ^{[1
]}

Minor, P. D. ^{[1
]}

机构：

[1] Natl Inst Biol Stand & Controls, CJD Resource Ctr, Potters Bar EN6 3QG, Herts, England

来源：

VOX SANGUINIS | 2007年 / 92卷 / 04期

关键词：

blood; CJD; diagnostics; infectivity; TSE;

D O I：

10.1111/j.1423-0410.2007.00904.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and Objectives A standard panel of materials is needed for the evaluation of assays being developed for the diagnosis of variant Creutzfeldt-Jakob disease. Materials and Methods Tissues from human and animals incubating transmissible spongiform encephalopathy disease have been prepared, aliquoted and where possible characterized by in vitro methods. Results A standardized preparation of materials has been generated. Conclusions Large-scale preparations of tissues and blood fractions can be used to directly compare the sensitivities of assays using different formats.

引用

页码：302 / 310

页数：9

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