Update on anti-tumor necrosis factor agents and other new drugs for inflammatory bowel disease

被引：119

作者：

Cohen, Benjamin L. ^{[1
]}

Sachar, David B. ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Susan & Leonard Feinstein Inflammatory Bowel Dis, Dr Henry D Janowitz Div Gastroenterol, New York, NY 10029 USA

来源：

BMJ-BRITISH MEDICAL JOURNAL | 2017年 / 357卷

关键词：

ANTI-TNF THERAPY; ACTIVE ULCERATIVE-COLITIS; SEVERE CROHNS-DISEASE; INFLIXIMAB MAINTENANCE THERAPY; PREVENTING POSTOPERATIVE RECURRENCE; NONMELANOMA SKIN CANCERS; EVIDENCE-BASED CONSENSUS; JANUS KINASE INHIBITOR; COMBINATION THERAPY; CLINICAL REMISSION;

D O I：

10.1136/bmj.j2505

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The treatment of inflammatory bowel disease (IBD)-ulcerative colitis (UC) and Crohn's disease (CD)-has evolved beyond surgery with the introduction of biologic agents, primarily antibodies against mediators of inflammation and cell attraction. Anti-tumor necrosis factor (TNF) agents have been the first line treatment for moderate to severe ulcerative colitis and Crohn's disease for more than 15 years. During that time much has been learnt about how best to use these agents. This review will assess the evidence on how to optimize the use of anti-TNF agents; when and how to start treatment; how to monitor treatment and when to de-escalate it; and the potential adverse effects of these drugs. New and emerging treatments such as anti-attractants, anti-interleukins, and Janus kinase (JAK) inhibitors will also be discussed.

引用

页数：17

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