The parathyroid hormone-related protein

被引：24

作者：

Strewler, GJ

机构：

[1] Harvard Univ, Sch Med, Dept Med, Boston, MA USA

[2] Vet Adm Boston Healthcare Syst, Dept Med, W Roxbury, MA USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2000年 / 29卷 / 03期

关键词：

D O I：

10.1016/S0889-8529(05)70154-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This article focuses on recent studies that add several new types of cancer to the range of tumors that have parathyroid hormone-related protein (PTHrP) as part of their repertoire. Topics include a new modus operandi for PTHrP as a mediator of local osteolysis around bone metastases, and tentative conclusions on the approach to using assays for PTHrP to aid in the differential diagnosis of hypercalcemia. PTHrP is vital to the normal functioning of mammals. Its role in adults and as a remarkably versatile regulator of development is apparently more ancient than the role of PTH and certainly more protean in action.

引用

收藏

页码：629 / +

页数：18

相关论文

共 107 条

[1]

Abe M, 1999, J BONE MINER RES, V14, pS163

[2] Programmed cell death of chondrocytes and aberrant chondrogenesis in mice homozygous for parathyroid hormone-related peptide gene deletion [J].

Amizuka, N ;

Henderson, JE ;

Hoshi, K ;

Warshawsky, H ;

Ozawa, H ;

Goltzman, D ;

Karaplis, AC .

ENDOCRINOLOGY, 1996, 137 (11) :5055-5067

[3] Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development [J].

Amling, M ;

Neff, L ;

Tanaka, S ;

Inoue, D ;

Kuida, K ;

Weir, E ;

Philbrick, WM ;

Broadus, AE ;

Baron, R .

JOURNAL OF CELL BIOLOGY, 1997, 136 (01) :205-213

[4]

[Anonymous], 1941, NEW ENGL J MED, V225, P789

[5] Solution structure of parathyroid hormone related protein (residues 1-34) containing an Ala substituted for an Ile in position 15 (PTHrP[Ala(15)]-(1-34)) [J].

Barden, JA ;

Cuthbertson, RM ;

Wu, JZ ;

Moseley, JM ;

Kemp, BE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (47) :29572-29578

[6] Histidine at position 5 is the specificity ''switch'' between two parathyroid hormone receptor subtypes [J].

Behar, V ;

Nakamoto, C ;

Greenberg, Z ;

Bisello, A ;

Suva, LJ ;

Rosenblatt, M ;

Chorev, M .

ENDOCRINOLOGY, 1996, 137 (10) :4217-4224

[7] Residues in the membrane-spanning and extracellular loop regions of the parathyroid hormone (PTH)-2 receptor determine signaling selectivity for PTH and PTH-related peptide [J].

Bergwitz, C ;

Jusseaume, SA ;

Luck, MD ;

Juppner, H ;

Gardella, TJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (46) :28861-28868

[8] CIRCULATING LEVELS OF MIDREGIONAL PARATHYROID HORMONE-RELATED PROTEIN IN HYPERCALCEMIA OF MALIGNANCY [J].

BLIND, E ;

RAUE, F ;

GOTZMANN, J ;

SCHMIDTGAYK, H ;

KOHL, B ;

ZIEGLER, R .

CLINICAL ENDOCRINOLOGY, 1992, 37 (03) :290-297

[9] LYMPHEDEMA HYPERCALCEMIA SYNDROME MEDIATED BY PARATHYROID-HORMONE-RELATED PROTEIN [J].

BRAUDE, S ;

GRAHAM, A ;

MITCHELL, D .

LANCET, 1991, 337 (8734) :140-141

[10]

Broadus Arthur E., 1994, P259

← 1 2 3 4 5 6 7 8 9 10 →