Preparation of an octadeoxyribonucleoside heptaphosphorothioate by the phosphotriester approach in solution

被引：11

作者：

Reese, CB ^{[1
]}

Song, QL

Rao, MV

Beckett, I

机构：

[1] Univ London Kings Coll, Dept Chem, London WC2R 2LS, England

[2] Cruachem Ltd, Glasgow G20 0UA, Lanark, Scotland

来源：

NUCLEOSIDES & NUCLEOTIDES | 1998年 / 17卷 / 1-3期

关键词：

D O I：

10.1080/07328319808005190

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of the octadeoxyribonucleoside heptaphosphorothioate, d[Tp(s)Tp(s)Gp(s)Gp(s)Gp(s)Gp(s)Tp(s)T] by the phosphotriester approach in solution is described. The phosphorothioate internucleotide linkages are protected by the S-(2-cyanoethyl) group and 1-(mesitylene-2-sulfonyl)-3-nitro-1,2,4-1H-triazole (MSNT) is used as the coupling agent. A block synthesis strategy (2 + 2 --> 4 and 4 + 4 --> 8) is followed.

引用

页码：451 / 470

页数：20

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