Caffeic acid phenethyl ester exerts a neuroprotective effect on CNS against pentylenetetrazol-induced seizures in mice

被引：72

作者：

Ilhan, A ^{[1
]}

Iraz, M

Gurel, A

Armutcu, F

Akyol, O

机构：

[1] Inonu Univ, Fac Med, Dept Neurol, Turgut Ozal Med Ctr, TR-44069 Malatya, Turkey

[2] Inonu Univ, Fac Med, Dept Pharmacol, TR-44069 Malatya, Turkey

[3] Karaelmas Univ, Fac Med, Dept Biochem, Zonguldak, Turkey

[4] Inonu Univ, Fac Med, Dept Biochem, TR-44069 Malatya, Turkey

来源：

NEUROCHEMICAL RESEARCH | 2004年 / 29卷 / 12期

关键词：

caffeic acid phenethyl ester; seizure; oxidative damage; brain;

D O I：

10.1007/s11064-004-7038-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since overexcitation of excitatory amino acid is an important mechanism in seizure genesis wherein free radicals have recently been suggested to play a critical role, we explored the effects of caffeic acid phenethyl ester (CAPE) administration in pentylenetetrazole (PTZ)-induced seizure in mice. CAPE prevents the oxidative damage in brain tissue induced by PTZ, scavenging reactive oxygen species (ROS). Our results demonstrate that CAPE treatment which prevents free radical production and ameliorates seizure severity may be useful at least as an adjunctive treatment of seizure disorders.

引用

页码：2287 / 2292

页数：6

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