Immunomodulatory activities of edible beans and related constituents from soybean

被引：31

作者：

Cherng, Jaw-Ming

Chiang, Wen

Chiang, Lien-Chai

机构：

[1] Kaohsiung Med Univ, Dept Lab Diag Microbiol, Fac Med, Coll Med, Kaohsiung 807, Taiwan

[2] Kaohsiung Med Univ, Dept Med, Fac Med, Coll Med, Kaohsiung 807, Taiwan

来源：

FOOD CHEMISTRY | 2007年 / 104卷 / 02期

关键词：

immunomodulation; interferon-gamma (IFN-gamma); interleukin 10 (IL-10); leguminosae; flavonoids;

D O I：

10.1016/j.foodchem.2006.12.011

中图分类号：

O69 [应用化学];

学科分类号：

081704 [应用化学];

摘要：

To explore the health-modulating constituents of common edible beans, their immunomodulatory activity on human peripheral blood mononuclear cells (PBMC) was evaluated. Studies were conducted on lymphocyte transformation by BrdU immunoassay, secretion of interferon-gamma (IFN-gamma) and interleukin 10 (IL-10) and elucidation of the responding cells by flow cytometry. The results at 20 mu g/mL showed that genistein, phytic acid and syringic acid induced a Th1-predominant immune response because they significantly suppressed the secretion of IL-10 and augmented the IFN-gamma production. The present study concludes that several non-nutritional ingredients of soybean such as flavonoids, plant acids and plant hormones most likely to be important in modulation of human immunity. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：613 / 618

页数：6

共 26 条

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