Synthesis of four natural prenylflavonoids and their estrogen-like activities

被引：51

作者：

Dong, Xiaowu ^{[1
]}

Fan, Yongjian ^{[1
]}

Yu, Lingjun ^{[1
]}

Hu, Yongzhou ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, ZJU ENS Joint Lab Med Chem, Hangzhou 310031, Zhejiang, Peoples R China

来源：

ARCHIV DER PHARMAZIE | 2007年 / 340卷 / 07期

关键词：

bavachin; 7,4 '-dihydroxyl-8-prenylflavone; estrogenic activity; 8-C-prenylapigenin; isobavachin;

D O I：

10.1002/ardp.200700057

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four prenylflavonoids, bavachin 1, isobavachin 2, 7,4'-dihydroxy-8-prenylflavone 3, and 8-prenyl-apigenin 4 were synthesized and recognized for possessing estrogen-like activity in MCF-7/BOS cells, as evaluated by an estrogen-screening assay. All compounds significantly stimulated the proliferation of MCF-7/BOS cells in a dose-dependent manner. Isobavachin 2 showed the most potent activity, while bavachin 1 was the weakest. The estrogenic potency of these compounds is ranked as follows: 2 > 4 > 3 > 1.

引用

页码：372 / 376

页数：5

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