Mechanisms of amyloidogenesis

被引：160

作者：

Kelly, JW ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

NATURE STRUCTURAL BIOLOGY | 2000年 / 7卷 / 10期

关键词：

D O I：

10.1038/82815

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Limitations of the three putative mechanisms of amyloid fibril assembly for explaining Sup35 prion formation have led to the introduction of a fourth model - nucleated conformational conversion - that invokes oligomeric: intermediates for initiation and assembly.

引用

页码：824 / 826

页数：3

共 9 条

[1] ROLE OF THE CHAPERONE PROTEIN HSP104 IN PROPAGATION OF THE YEAST PRION-LIKE FACTOR [PSI(+)] [J].

CHERNOFF, YO ;

LINDQUIST, SL ;

ONO, B ;

INGEVECHTOMOV, SG ;

LIEBMAN, SW .

SCIENCE, 1995, 268 (5212) :880-884

[2] A critical role for amino-terminal glutamine/asparagine repeats in the formation and propagation of a yeast prion [J].

DePace, AH ;

Santoso, A ;

Hillner, P ;

Weissman, JS .

CELL, 1998, 93 (07) :1241-1252

[3] Self-seeded fibers formed by Sup35, the protein determinant of [PSI+], a heritable prion-like factor of S-cerevisiae [J].

Glover, JR ;

Kowal, AS ;

Schirmer, EC ;

Patino, MM ;

Liu, JJ ;

Lindquist, S .

CELL, 1997, 89 (05) :811-819

[4] SELF-REPLICATION AND SCRAPIE [J].

GRIFFITH, JS .

NATURE, 1967, 215 (5105) :1043-&

[5] Assembly of Aβ amyloid protofibrils:: An in vitro model for a possible early event in Alzheimer's disease [J].

Harper, JD ;

Wong, SS ;

Lieber, CM ;

Lansbury, PT .

BIOCHEMISTRY, 1999, 38 (28) :8972-8980

[6] SEEDING ONE-DIMENSIONAL CRYSTALLIZATION OF AMYLOID - A PATHOGENIC MECHANISM IN ALZHEIMERS-DISEASE AND SCRAPIE [J].

JARRETT, JT ;

LANSBURY, PT .

CELL, 1993, 73 (06) :1055-1058

[7] NOVEL PROTEINACEOUS INFECTIOUS PARTICLES CAUSE SCRAPIE [J].

PRUSINER, SB .

SCIENCE, 1982, 216 (4542) :136-144

[8] Nucleated conformational conversion and the replication of conformational information by a prion determinant [J].

Serio, TR ;

Cashikar, AG ;

Kowal, AS ;

Sawicki, GJ ;

Moslehi, JJ ;

Serpell, L ;

Arnsdorf, MF ;

Lindquist, SL .

SCIENCE, 2000, 289 (5483) :1317-1321

[9] The nanometer-scale structure of amyloid-beta visualized by atomic force microscopy [J].

Stine, WB ;

Snyder, SW ;

Ladror, US ;

Wade, WS ;

Miller, MF ;

Perun, TJ ;

Holzman, TF ;

Krafft, GA .

JOURNAL OF PROTEIN CHEMISTRY, 1996, 15 (02) :193-203

← 1 →