New Opportunities for an Ancient Material

被引:1195
作者
Omenetto, Fiorenzo G. [1 ]
Kaplan, David L. [1 ]
机构
[1] Tufts Univ, Dept Biomed Engn, Medford, MA 02155 USA
基金
美国国家科学基金会;
关键词
SPIDER DRAGLINE SILK; PROTEINS; FIBROIN; FIBER; POLYMERS; STRENGTH; SEQUENCE; GENES; FILMS;
D O I
10.1126/science.1188936
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Spiders and silkworms generate silk protein fibers that embody strength and beauty. Orb webs are fascinating feats of bioengineering in nature, displaying magnificent architectures while providing essential survival utility for spiders. The unusual combination of high strength and extensibility is a characteristic unavailable to date in synthetic materials yet is attained in nature with a relatively simple protein processed from water. This biological template suggests new directions to emulate in the pursuit of new high-performance, multifunctional materials generated with a green chemistry and processing approach. These bio-inspired and high-technology materials can lead to multifunctional material platforms that integrate with living systems for medical materials and a host of other applications.
引用
收藏
页码:528 / 531
页数:4
相关论文
共 31 条
[1]   Silk-based biomaterials [J].
Altman, GH ;
Diaz, F ;
Jakuba, C ;
Calabro, T ;
Horan, RL ;
Chen, JS ;
Lu, H ;
Richmond, J ;
Kaplan, DL .
BIOMATERIALS, 2003, 24 (03) :401-416
[2]   Self-assembly of spider silk proteins is controlled by a pH-sensitive relay [J].
Askarieh, Glareh ;
Hedhammar, My ;
Nordling, Kerstin ;
Saenz, Alejandra ;
Casals, Cristina ;
Rising, Anna ;
Johansson, Jan ;
Knight, Stefan D. .
NATURE, 2010, 465 (7295) :236-U125
[3]   Blueprint for a High-Performance Biomaterial: Full-Length Spider Dragline Silk Genes [J].
Ayoub, Nadia A. ;
Garb, Jessica E. ;
Tinghitella, Robin M. ;
Collin, Matthew A. ;
Hayashi, Cheryl Y. .
PLOS ONE, 2007, 2 (06)
[4]   Materials science - Silk and sequence [J].
Calvert, P .
NATURE, 1998, 393 (6683) :309-+
[5]   GENETIC-ENGINEERING OF STRUCTURAL PROTEIN POLYMERS [J].
CAPPELLO, J ;
CRISSMAN, J ;
DORMAN, M ;
MIKOLAJCZAK, M ;
TEXTOR, G ;
MARQUET, M ;
FERRARI, F .
BIOTECHNOLOGY PROGRESS, 1990, 6 (03) :198-202
[6]   Synthetic spider dragline silk proteins and their production in Escherichia coli [J].
Fahnestock, SR ;
Irwin, SL .
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 1997, 47 (01) :23-32
[7]   Role of pH and charge on silk protein assembly in insects and spiders [J].
Foo, CWP ;
Bini, E ;
Hensman, J ;
Knight, DP ;
Lewis, RV ;
Kaplan, DL .
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING, 2006, 82 (02) :223-233
[8]  
Gosline JM, 1999, J EXP BIOL, V202, P3295
[9]   A conserved spider silk domain acts as a molecular switch that controls fibre assembly [J].
Hagn, Franz ;
Eisoldt, Lukas ;
Hardy, John G. ;
Vendrely, Charlotte ;
Coles, Murray ;
Scheibel, Thomas ;
Kessler, Horst .
NATURE, 2010, 465 (7295) :239-U131
[10]   Molecular architecture and evolution of a modular spider silk protein gene [J].
Hayashi, CY ;
Lewis, RV .
SCIENCE, 2000, 287 (5457) :1477-1479