Misleading results with the 14-3-3 assay for the diagnosis of Creutzfeldt-Jakob disease

被引：52

作者：

Chapman, T

McKeel, DW

Morris, JC

机构：

[1] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USA

来源：

NEUROLOGY | 2000年 / 55卷 / 09期

关键词：

D O I：

10.1212/WNL.55.9.1396

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The definitive diagnosis of Creutzfeldt-Jakob disease (CJD) requires brain tissue analysis. A positive assay for the 14-3-3 protein in CSF has been suggested to be highly sensitive and specific in patients with CJD. The authors describe three patients for whom CSF 14-3-3 assays were falsely positive or falsely negative. Caution against overreliance on this putative biomarker is suggested in the diagnosis of CJD.

引用

页码：1396 / 1397

页数：2

共 11 条

[1] Abnormal diffusion-weighted magnetic resonance images in Creutzfeldt-Jakob disease
Bahn, MM
Parchi, P
[J]. ARCHIVES OF NEUROLOGY, 1999, 56 (05) : 577 - 583
[2] BROWN P, 1994, HDB DEMENTING ILLNES, P353
[3] Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent
Bruce, ME
Will, RG
Ironside, JW
McConnell, I
Drummond, D
Suttie, A
McCardle, L
Chree, A
Hope, J
Birkett, C
Cousens, S
Fraser, H
Bostock, CJ
[J]. NATURE, 1997, 389 (6650) : 498 - 501
[4] The 14-3-3 brain protein in cerebrospinal fluid as a marker for transmissible spongiform encephalopathies
Hsich, G
Kinney, K
Gibbs, CJ
Lee, KH
Harrington, MG
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (13) : 924 - 930
[5] Parker JC, 1999, ANN CLIN LAB SCI, V29, P112
[6] How to improve the clinical diagnosis of Creutzfeldt-Jakob disease
Poser, S
Mollenhauer, B
Krauss, A
Zerr, I
Steinhoff, BJ
Schroeter, A
Finkenstaedt, M
Schulz-Schaeffer, WJ
Kretzschmar, HA
Felgenhauer, K
[J]. BRAIN, 1999, 122 : 2345 - 2351
[7] PRUISINER SB, 1994, ANN NEUROL, V35, P385
[8] Saiz A, 1999, ANN NEUROL, V46, P774, DOI 10.1002/1531-8249(199911)46:5<774::AID-ANA14>3.0.CO
[9] 2-N
[10] Cerebrospinal-fluid test for new-variant Creutzfeldt-Jakob disease
Will, RG
Zeidler, M
Brown, P
Harrington, M
Lee, KH
Kenney, KL
[J]. LANCET, 1996, 348 (9032) : 955 - 955

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