Association between the G1246A polymorphism of the hypocretin receptor 2 gene and cluster headache:: a meta-analysis

被引：45

作者：

Rainero, Innocenzo

Rubino, Elisa

Valfre, Walter

Gallone, Salvatore

De Martino, Paola

Zampella, Erika

Pinessi, Lorenzo

机构：

[1] Neurology II - Headache Centre, Department of Neuroscience, University of Turin, I-10126 Torino

来源：

JOURNAL OF HEADACHE AND PAIN | 2007年 / 8卷 / 03期

关键词：

meta-analysis; genetic association; cluster headache; G1246A polymorphism; hypocretin receptor 2 gene;

D O I：

10.1007/s10194-007-0383-x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The objective of this study was to investigate the association between polymorphisms of the hypocretin receptor 2 gene (HCRTR2) and the risk of cluster headache (CH). The study is a meta-analysis of published case-control studies investigating the association between polymorphisms of the HCRTR2 gene and CH. Pooled odds ratios (OR) were estimated using both random (RE) and fixed effects (FE) models. Three studies, performed in five different European countries, with 593 cases and 599 controls, were included in the study. Allele G of the G1246A HCRTR2 polymorphism was significantly associated with CH (FE OR 1.58, CI 95% 1.27-1.95; RE OR 1.55 (1.14-2.12)). Carriers of the GG genotype showed a higher disease risk compared to the remaining genotypes (FE OR 1.75, CI 95% 1.37-2.25; RE OR 1.69, CI 95% 1.11-2.58). Our data confirm that the G1246A polymorphism of the HCRTR2 gene may modulate the genetic risk for CH.

引用

页码：152 / 156

页数：5

共 25 条

[1]

Goadsby P.J., Pathophysiology of cluster headache: A trigeminal Autonomic cephalgia, Lancet Neurol, 1, pp. 251-257, (2002)

[2]

Torelli P., Beghi E., Manzoni G.C., Cluster headache prevalence in the Italian general population, Neurology, 64, pp. 469-474, (2005)

[3]

Russell M.B., Andersson P.G., Thomsen L.L., Familial occurrence of cluster headache, J Neurol Neurosurg Psychiatry, 58, pp. 341-343, (1995)

[4]

Leone M., Russell M.B., Rigamonti A., Et al., Increased familial risk of cluster headache, Neurology, 56, pp. 1233-1236, (2001)

[5]

El Amrani M., Ducros A., Boulan P., Et al., Familial cluster headache: A series of 186 index patients, Headache, 42, pp. 974-977, (2002)

[6]

Russell M.B., Andersson P.G., Thomsen L.L., Iselius L., Cluster headache is an autosomal dominantly inherited disorder in some families: A complex segregation analysis, J Clin Genet, 32, pp. 954-956, (1995)

[7]

Pinessi L., Rainero I., Rivoiro C., Et al., Genetics of cluster headache: An update, J Headache Pain, 6, pp. 234-236, (2005)

[8]

Russell M.B., Epidemiology and genetics of cluster headache, Lancet Neurol, 3, pp. 279-283, (2004)

[9]

Sakurai T., Amemiya A., Ishii M., Et al., Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior, Cell, 92, pp. 573-585, (1998)

[10]

Nishino S., The hypocretin/orexin system in health and disease, Biol Psychiatry, 54, pp. 87-95, (2003)

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