In vivo antioxidant activity of polysaccharide fraction from Porphyra haitanesis (Rhodephyta) in aging mice

被引：236

作者：

Zhang, QB

Li, N

Zhou, GF

Lu, XL

Xu, ZH

Li, Z ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

[3] Ocean Univ China, Coll Chem & Chem Engn, Qingdao 266003, Peoples R China

来源：

PHARMACOLOGICAL RESEARCH | 2003年 / 48卷 / 02期

关键词：

Porphyra haitanesis; polysaccharide; aging; lipid peroxidation;

D O I：

10.1016/S1043-6618(03)00103-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Sulfated polysaccharide fraction F2 from Porphyra haitanesis (Rhodephyta) showed inhibitory effect on the in vitro lipid peroxidation. In the present study, the age-related changes in the antioxidant enzyme activity, lipid peroxidation, and total antioxidant capacity (TAOC) in different organs in mice were investigated and the in vivo antioxidant effect of F2 in aging mice was checked. Increased endogenous lipid peroxidation and decreased TAOC were observed in aging mice. Intraperitoneal administration of F2 significantly decreased the lipid peroxidation in a dose-dependent manner. F2 treatment increased TAOC and the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in all the organs tested in aging mice. It is concluded that the sulfated polysaccharide fraction F2 can be used in compensating the decline in TAOC and the activities of antioxidant enzymes and thereby reduces the risks of lipid peroxidation. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：151 / 155

页数：5

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