Studies on development of sufficiently chemoselective N-acylation reagents:: N-acyl-N-(2,3,4,5,6-pentafluorophenyl)methanesulfonamides

被引：79

作者：

Kondo, K ^{[1
]}

Sekimoto, E ^{[1
]}

Nakao, J ^{[1
]}

Murakami, Y ^{[1
]}

机构：

[1] Toho Univ, Sch Pharmaceut Sci, Chiba 2748510, Japan

来源：

TETRAHEDRON | 2000年 / 56卷 / 32期

关键词：

chemoselective N-acylation reagent; alkoxycarbonylation; sulfonamide; amine; protective group;

D O I：

10.1016/S0040-4020(00)00549-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A variety of storable N-acyl-N-(2,3,4,5,6-pentafluorophenyl)met (4a-e) prepared from N-2,3,4,5,6-pentafluorophenylmethanesulfonamide (3), have been developed after systematic research on the structure-reactivity relationship and were found to serve as N-acylation reagents exhibiting sufficiently good chemoselectivity. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：5843 / 5856

页数：14

共 37 条

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AKIKUSA N, 1992, SYNTHESIS-STUTTGART, P1058

[2] N-acetyl-N-acyl-3-aminoquinazolinones as chemoselective acetylating agents [J].