Alternative therapy of Alzheimer's disease via supplementation with choline acetyltransferase

被引：35

作者：

Fu, AL ^{[1
]}

Li, Q ^{[1
]}

Dong, ZH ^{[1
]}

Huang, SJ ^{[1
]}

Wang, YX ^{[1
]}

Sun, MJ ^{[1
]}

机构：

[1] Inst Pharmacol & Toxicol, Dept Biochem & Pharmacol, Beijing 100850, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2004年 / 368卷 / 03期

关键词：

choline acetyltransferase; TAT protein transduction domain; Alzheimer's disease; protein therapy;

D O I：

10.1016/j.neulet.2004.05.116

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Much evidence indicates that the memory and cognitive deficits of patients with Alzheimer's disease are closely associated with dysfunction of central cholinergic system. The degree of reduction of choline acetyltransferase activity in cerebral cholinergic neurons is significantly correlated with the severity of dementia or cognitive impairments observed in Alzheimer's disease. Therefore, Alzheimer's disease may be slowed by supplementation of exogenous choline acetyltransferase. Here we show that choline acetyltransferase mediated by TAT protein transduction domain passes through the blood-brain barrier and enters the neurons in mice, increasing choline acetyltransferase and neurotransmitter acetylcholine contents. The recombination TAT-choline acetyltransferase fusion protein injected intravenously improves the memory and cognitive dysfunction in Alzheimer's disease model mice induced by amyloid-P peptide. Our results imply a novel and potentially effective way for Alzheimer's disease therapy. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：258 / 262

页数：5

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