Extending Cord Blood Transplant to Adults: Dealing With Problems and Results Overall

被引：19

作者：

Brunstein, Claudio G. ^{[1
]}

Laughlin, Mary J. ^{[2
]}

机构：

[1] Univ Minnesota, Dept Med, Blood & Marrow Transplant Program, Div Hematol Oncol & Transplantat, Minneapolis, MN 55455 USA

[2] Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA

来源：

SEMINARS IN HEMATOLOGY | 2010年 / 47卷 / 01期

关键词：

STEM-CELL TRANSPLANTATION; INTENSITY PREPARATIVE REGIMEN; SINGLE-INSTITUTE ANALYSIS; COMPLEMENT COMPONENT C3; VERSUS-HOST-DISEASE; UNRELATED DONORS; BONE-MARROW; PROGENITOR CELLS; ACUTE-LEUKEMIA; HEMATOLOGIC MALIGNANCIES;

D O I：

10.1053/j.seminhematol.2009.10.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The development of newer strategies to overcome, in particular, the cell dose limitation, has increased the availability of umbilical cord blood (UCB) as a source of hematopoietic stem cells (HSC) for transplantation of adults. Among these strategies is the development of the double UCB, ex vivo, and reduced-intensity transplantation platforms. Several ongoing registry-based and single-institution and multicenter clinical trials are investigating ways to make UCB transplantation safer and to improve the outcomes of adults after UCB transplantation. We review the background data and promising newer strategies that will further expand the utilization of UCB for the treatment of adults. Semin Hematol 47:86-96. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：86 / 96

页数：11

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