Insulin decreases human adiponectin plasma levels

被引:100
作者
Möhlig, M
Wegewitz, U
Osterhoff, M
Isken, F
Ristow, M
Pfeiffer, AFH
Spranger, J
机构
[1] Free Univ Berlin, Benjamin Franklin Med Ctr, Dept Endocrinol Diabet & Nutr, D-12200 Berlin, Germany
[2] German Inst Human Nutr Potsdam, Dept Clin Nutr, Bergholz Rehbrucke, Germany
关键词
adiponectin; insulin resistance; atherosclerosis; diabetes; insulin; cytokine; obesity;
D O I
10.1055/s-2002-38248
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Insulin resistance and hyperinsulinemia are known atherosclerosis risk factors. The association between adiponectin plasma levels and obesity, insulinemia, and atherosclerosis has been shown. Thus, adiponectin may be a link between hyperinsulinemia and vascular disease. In vitro data demonstrated a reduction of adiponectin expression by insulin. However, it is still unclear whether insulin regulates adiponectinemia in vivo in humans. Five healthy male volunteers were studied. Circulating adiponectin levels were determined before and during hyperinsulinemic euglycemic clamp. Adiponectin was measured by radioimmunoassay. Hyperinsulinemia (85.0 +/- 33.2 at baseline vs. 482.8 +/- 64.4pmol/l during steady state; p < 0.01) was achieved using a euglycemic hyperinsulinemic clamp, keeping blood glucose levels basically unchanged during the intervention (4.6 +/- 0.14 vs. 4.37 +/- 0.15 mmol/l, respectively; ns). We found a significant decrease of adiponectin plasma levels during the steady state of hyperinsulinemic euglycemic clamp (26.7 +/- 3.5 mug/ml) compared to baseline levels (30.4 +/- 5 mug/ml; p < 0.05). Hyperinsulinemia caused a significant decrease of adiponectin plasma levels under euglycemic conditions. Considering existing data about adiponectin dependent effects, hypoadiponectinemia might at least partly be a link between hyperinsulinemia and vascular disease in metabolic syndrome.
引用
收藏
页码:655 / 658
页数:4
相关论文
共 31 条
[1]  
[Anonymous], 2002, DIABETES CARE S1, V25, pS5
[2]   The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome [J].
Comuzzie, AG ;
Funahashi, T ;
Sonnenberg, G ;
Martin, LJ ;
Jacob, HJ ;
Black, AEK ;
Maas, D ;
Takahashi, M ;
Kihara, S ;
Tanaka, S ;
Matsuzawa, Y ;
Blangero, J ;
Cohen, D ;
Kissebah, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (09) :4321-4325
[3]  
DEFRONZO RA, 1979, AM J PHYSIOL, V237, pE214
[4]   Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes [J].
Fasshauer, M ;
Klein, J ;
Neumann, S ;
Eszlinger, M ;
Paschke, R .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 290 (03) :1084-1089
[5]   Adiponectin gene expression is inhibited by β-adrenergic stimulation via protein kinase A in 3T3-L1 adipocytes [J].
Fasshauer, M ;
Klein, J ;
Neumann, S ;
Eszlinger, M ;
Paschke, R .
FEBS LETTERS, 2001, 507 (02) :142-146
[6]   Role of adipocytokines on the pathogenesis of atherosclerosis in visceral obesity [J].
Funahashi, T ;
Nakamura, T ;
Shimomura, I ;
Maeda, K ;
Kuriyama, H ;
Takahashi, M ;
Arita, Y ;
Kihara, S ;
Matsuzawa, Y .
INTERNAL MEDICINE, 1999, 38 (02) :202-206
[7]   Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population [J].
Hara, K ;
Boutin, P ;
Mori, Y ;
Tobe, K ;
Dina, C ;
Yasuda, K ;
Yamauchi, T ;
Otabe, S ;
Okada, T ;
Eto, K ;
Kadowaki, H ;
Hagura, R ;
Akanuma, Y ;
Yazaki, Y ;
Nagai, R ;
Taniyama, M ;
Matsubara, K ;
Yoda, M ;
Nakano, Y ;
Kimura, S ;
Tomita, M ;
Kimura, S ;
Ito, C ;
Froguel, P ;
Kadowaki, T .
DIABETES, 2002, 51 (02) :536-540
[8]   Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients [J].
Hotta, K ;
Funahashi, T ;
Arita, Y ;
Takahashi, M ;
Matsuda, M ;
Okamoto, Y ;
Iwahashi, H ;
Kuriyama, H ;
Ouchi, N ;
Maeda, K ;
Nishida, M ;
Kihara, S ;
Sakai, N ;
Nakajima, T ;
Hasegawa, K ;
Muraguchi, M ;
Ohmoto, Y ;
Nakamura, T ;
Yamashita, S ;
Hanafusa, T ;
Matsuzawa, Y .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (06) :1595-1599
[9]   AdipoQ is a novel adipose-specific gene dysregulated in obesity [J].
Hu, E ;
Liang, P ;
Spiegelman, BM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (18) :10697-10703
[10]   Association of adiponectin mutation with type 2 diabetes - A candidate gene for the insulin resistance syndrome [J].
Kondo, H ;
Shimomura, I ;
Matsukawa, Y ;
Kumada, M ;
Takahashi, M ;
Matsuda, M ;
Ouchi, N ;
Kihara, S ;
Kawamoto, T ;
Sumitsuji, S ;
Funahashi, T ;
Matsuzawa, Y .
DIABETES, 2002, 51 (07) :2325-2328