Notch3 is required for arterial identity and maturation of vascular smooth muscle cells

被引：411

作者：

Domenga, V

Fardoux, P

Lacombe, P

Monet, M

Maciazek, J

Krebs, LT

Klonjkowski, B

Berrou, E

Mericskay, M

Li, Z

Tournier-Lasserve, E

Gridley, T

Joutel, A ^{[1
]}

机构：

[1] INSERM, E365, Fac Med Lariboisiere, F-75010 Paris, France

[2] Jackson Lab, Bar Harbor, ME 04609 USA

[3] INRA, UMR1161, ENVA, AFSSA Virol, F-94704 Maisons Alfort, France

[4] Hop Lariboisiere, INSERM, U348, F-75010 Paris, France

[5] Hop Lariboisiere, Lab Cytogenet, F-75010 Paris, France

[6] Univ Paris 07, F-75251 Paris, France

来源：

GENES & DEVELOPMENT | 2004年 / 18卷 / 22期

关键词：

Notch3; artery; smooth muscle cell; differentiation;

D O I：

10.1101/gad.308904

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Formation of a fully functional artery proceeds through a multistep process. Here we show that Notch3 is required to generate functional arteries in mice by regulating arterial differentiation and maturation of vascular smooth muscle cells (vSMC). In adult Notch3(-/-) mice distal arteries exhibit structural defects and arterial myogenic responses are defective. The postnatal maturation stage of vSMC is deficient in Notch3(-/-) mice. We further show that Notch3 is required for arterial specification of vSMC but not of endothelial cells. Our data reveal Notch3 to be the first cell-autonomous regulator of arterial differentiation and maturation of vSMC.

引用

收藏

页码：2730 / 2735

页数：6

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