A facile demethylation of ortho substituted aryl methyl ethers promoted by AlCl3

被引：24

作者：

Du, Zhen-Ting ^{[1
]}

Lu, Jing ^{[1
]}

Yu, Hong-Rui ^{[1
]}

Xu, Yan ^{[1
]}

Li, An-Pai ^{[2
]}

机构：

[1] NW A&F Univ, Coll Sci, Yangling 712100, Shaanxi, Peoples R China

[2] Synthet Technol Pte Ltd, Singapore 048693, Singapore

来源：

JOURNAL OF CHEMICAL RESEARCH | 2010年 / 04期

基金：

中国国家自然科学基金;

关键词：

demethylation; aluminium chloride; phenol methyl ethers; nimbosidione; ALKYL ETHERS; ACID; CLEAVAGE; DEPROTECTION; SYSTEM;

D O I：

10.3184/030823410X12708998015900

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

An efficient and practical demethylation of ortho substituted aryl methyl ethers using AlCl3 has been developed. This method gives a high conversion, is simple to operate and is cost-effective. A mechanism involving the complexation of AlCl3 with the OMe and the adjacent electron withdrawing group is proposed. Many functional groups can be tolerated in the demethylation process, and 29 examples gave a demethylated product in a yield of 90-98%.

引用

收藏

页码：222 / 227

页数：6

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