Long non-coding RNA FEZF1-AS1 facilitates cell proliferation and migration in colorectal carcinoma

被引：113

作者：

Chen, Na ^{[1
,2
]}

Guo, Dan ^{[3
]}

Xu, Qiong ^{[1
,2
]}

Yang, Minhui ^{[1
,2
]}

Wang, Dan ^{[1
]}

Peng, Man ^{[1
]}

Ding, Yanqing ^{[2
]}

Wang, Shuang ^{[1
,2
]}

Zhou, Jun ^{[1
,2
]}

机构：

[1] Southern Med Univ, Nanfang Hosp, Dept Pathol, Guangzhou 510515, Guangdong, Peoples R China

[2] Southern Med Univ, Sch Basic Med Sci, Dept Pathol, Guangzhou 510515, Guangdong, Peoples R China

[3] Southern Med Univ, Nanfang Hosp, Dept Pharm, Guangzhou 510515, Guangdong, Peoples R China

来源：

ONCOTARGET | 2016年 / 7卷 / 10期

关键词：

FEZF1-AS1; FEZF1; colorectal cancer; long non-coding RNA; GASTRIC-CANCER; EXPRESSION; METASTASIS; PROMOTES; PROGNOSIS; MALAT1; SIGNATURE; APOPTOSIS; HOTAIR; LINKS;

D O I：

10.18632/oncotarget.7168

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Long non-coding RNAs (lncRNA) have been shown to play important roles in the development and progression of cancer. Here, we discovered a novel long noncoding RNA (lncRNA) FEZF1 antisense RNA1 (FEZF1-AS1) is markedly upregulated in human primary colorectal carcinoma (CRC) and associated with CRC metastasis and poor prognosis. Moreover, the downregulation of FEZF1-AS1 expression significantly inhibited the CRC cells proliferation, migration and invasiveness, suppressed S-phase entry in vitro, and repressed tumor growth and metastasis in vivo. In contrast, overexpression of FEZF1-AS1 could promote the aggressive behaviors of CRC cells. We further discovered that the downregulation of FEZF1-AS1 reduced its sense-cognate gene FEZF1 mRNA and protein expression in CRC cells. There was a positive correlation between FEZF1-AS1 and FEZF1 expression in CRC. Moreover, FEZF1 knockdown also significantly suppressed CRC cell proliferation, migration, and invasion. Our findings indicate that the dysregulation of FEZF1-AS1 participates in colorectal tumorigenesis and progression, which might be achieved, at least in part, through FEZF1 induction.

引用

页码：11271 / 11283

页数：13

共 36 条

[1]

microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer [J].

Braconi, C. ;

Kogure, T. ;

Valeri, N. ;

Huang, N. ;

Nuovo, G. ;

Costinean, S. ;

Negrini, M. ;

Miotto, E. ;

Croce, C. M. ;

Patel, T. .

ONCOGENE, 2011, 30 (47) :4750-4756

[2]

HOTAIR: a cancer-related long non-coding RNA [J].

Cai, B. ;

Song, X. Q. ;

Cai, J. P. ;

Zhang, S. .

NEOPLASMA, 2014, 61 (04) :379-391

[3]

Cui Z., 2012, UROL ONCOL, V31, P1117, DOI DOI 10.1016/J.UR0L0NC.2011.11.030

[4]

Genetics, diagnosis and management of colorectal cancer [J].

De Rosa, Marina ;

Pace, Ugo ;

Rega, Daniela ;

Costabile, Valeria ;

Duraturo, Francesca ;

Izzo, Paola ;

Delrio, Paolo .

ONCOLOGY REPORTS, 2015, 34 (03) :1087-1096

[5]

TGF-β-Induced Upregulation of malat1 Promotes Bladder Cancer Metastasis by Associating with suz12 [J].

Fan, Yu ;

Shen, Bing ;

Tan, Mingyue ;

Mu, Xinyu ;

Qin, Yan ;

Zhang, Fang ;

Liu, Yong .

CLINICAL CANCER RESEARCH, 2014, 20 (06) :1531-1541

[6]

EFNA3 long noncoding RNAs induced by hypoxia promote metastatic dissemination [J].

Gomez-Maldonado, L. ;

Tiana, M. ;

Roche, O. ;

Prado-Cabrero, A. ;

Jensen, L. ;

Fernandez-Barral, A. ;

Guijarro-Munoz, I. ;

Favaro, E. ;

Moreno-Bueno, G. ;

Sanz, L. ;

Aragones, J. ;

Harris, A. ;

Volpert, O. ;

Jimenez, B. ;

del Peso, L. .

ONCOGENE, 2015, 34 (20) :2609-2620

[7]

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis [J].

Gupta, Rajnish A. ;

Shah, Nilay ;

Wang, Kevin C. ;

Kim, Jeewon ;

Horlings, Hugo M. ;

Wong, David J. ;

Tsai, Miao-Chih ;

Hung, Tiffany ;

Argani, Pedram ;

Rinn, John L. ;

Wang, Yulei ;

Brzoska, Pius ;

Kong, Benjamin ;

Li, Rui ;

West, Robert B. ;

van de Vijver, Marc J. ;

Sukumar, Saraswati ;

Chang, Howard Y. .

NATURE, 2010, 464 (7291) :1071-U148

[8]

The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells [J].

Gutschner, Tony ;

Haemmerle, Monika ;

Eissmann, Moritz ;

Hsu, Jeff ;

Kim, Youngsoo ;

Hung, Gene ;

Revenko, Alexey ;

Arun, Gayatri ;

Stentrup, Marion ;

Gross, Matthias ;

Zoernig, Martin ;

MacLeod, A. Robert ;

Spector, David L. ;

Diederichs, Sven .

CANCER RESEARCH, 2013, 73 (03) :1180-1189

[9]

lincRNAs act in the circuitry controlling pluripotency and differentiation [J].

Guttman, Mitchell ;

Donaghey, Julie ;

Carey, Bryce W. ;

Garber, Manuel ;

Grenier, Jennifer K. ;

Munson, Glen ;

Young, Geneva ;

Lucas, Anne Bergstrom ;

Ach, Robert ;

Bruhn, Laurakay ;

Yang, Xiaoping ;

Amit, Ido ;

Meissner, Alexander ;

Regev, Aviv ;

Rinn, John L. ;

Root, David E. ;

Lander, Eric S. .

NATURE, 2011, 477 (7364) :295-U60

[10]

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals [J].

Guttman, Mitchell ;

Amit, Ido ;

Garber, Manuel ;

French, Courtney ;

Lin, Michael F. ;

Feldser, David ;

Huarte, Maite ;

Zuk, Or ;

Carey, Bryce W. ;

Cassady, John P. ;

Cabili, Moran N. ;

Jaenisch, Rudolf ;

Mikkelsen, Tarjei S. ;

Jacks, Tyler ;

Hacohen, Nir ;

Bernstein, Bradley E. ;

Kellis, Manolis ;

Regev, Aviv ;

Rinn, John L. ;

Lander, Eric S. .

NATURE, 2009, 458 (7235) :223-227

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