Synthesis and study of antibacterial and antifungal activities of novel 2-[[(benzoxazole/benzimidazole-2-yl)sulfanyl] acetylamino]thiazoles

被引：71

作者：

Kaplancikli, ZA ^{[1
]}

Turan-Zitouni, G

Revial, G

Guven, K

机构：

[1] Anadolu Univ, Fac Pharm, Dept Pharmaceut Chem, TR-26470 Eskisehir, Turkey

[2] ESPCI, ESA 7084, CNRS, Chim Organ Lab, F-75231 Paris 05, France

[3] Anadolu Univ, Fac Sci, Dept Biol, TR-26470 Eskisehir, Turkey

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2004年 / 27卷 / 11期

关键词：

thiazole; benzoxazole; benzimidazole; antimicrobial activity;

D O I：

10.1007/BF02975108

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Several 2-[[(benzoxazole/benzimidazole-2-yl)sulfanyl]acetylamino]thiazoles derivatives were synthesized by reacting 4-substituted-2-(chloroacetylamino)thiazoles with benzoxazole/benzimidazole-2-thioles in acetone and in the presence of K2CO3. The chemical structures of the compounds were elucidated by IR, H-1-NMR, and FAB(+)-MS spectral data. Their antimicrobial activities against Micrococcus luteus (NRLL B-4375), Bacillus cereus (NRRL B-3711), Proteus vulgaris (NRRL B-123), Salmonella typhimurium (NRRL B-4420), Staphylococcus aureus (NRRL B-767), Escherichia coli (NRRL B-3704), Candida albicans and Candida globrata (isolates obtained from Osmangazi Uni. Fac. of Medicine) were investigated and in this investigation, a significant level of activity was illustrated.

引用

页码：1081 / 1085

页数：5

共 30 条

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Antifungal resistance trends towards the year 2000 - Implications for therapy and new approaches [J].