Immune regulation by microvascular endothelial cells: Directing innate and adaptive immunity, coagulation, and inflammation

An effective immune response depends not only on the proper activation, regulation, and function of immune cells, hut also on their distribution and retention in diverse tissue mi. croenvironments where they encounter a number of stimuli and other cell types. These activities are mediated by endiothelial cells, which form specialized microcirculatory networks used by immune cells under both physiological and pathological circumstances. Endothelial cells represent a highly heterogeneous population of cells with the ability to interact with and modulate the function of immune cells. This review is focused on the role of microvascular endothelial cells in innate and adaptive immunity, inflammation, coagulation, angiogenesis, and the therapeutic implications of targeting endothelial cells in selected autoimmune and chronic inflammatory disorders. The Journal of Immunology, 2007, 178: 6017-6022.