Genetic and biochemical diversity in the Pax gene family

被引：48

作者：

Underhill, DA ^{[1
]}

机构：

[1] Univ Alberta, Dept Med Genet, Edmonton, AB T6G 2H7, Canada

来源：

BIOCHEMISTRY AND CELL BIOLOGY | 2000年 / 78卷 / 05期

关键词：

Pax; paired domain; homeodomain; development; gene regulation;

D O I：

10.1139/bcb-78-5-629

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mammalian Pax gene family comprises nine members that are characterized by a conserved DNA-binding motif, the paired domain, which was originally described in the Drosophila protein paired. Both loss- and gain-of-function studies reveal that Pax genes carry out essential roles during embryogenesis, and in some instances, may function as master regulatory genes. This review focuses on both genetic and biochemical aspects of the Pax family, and emphasizes important differences in the activity of individual Pax genes and their protein products.

引用

页码：629 / 638

页数：10

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