Sarcoglycans of the zebrafish: orthology and localization to the sarcolemma and myosepta of muscle

被引：18

作者：

Chambers, SP

Anderson, LVB

Maguire, GM

Dodd, A

Love, DR

机构：

[1] Univ Auckland, Mol Genet & Dev Grp, Sch Biol Sci, Auckland 1, New Zealand

[2] Univ Newcastle Upon Tyne, Sch Med, Dept Neurobiol, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 303卷 / 02期

关键词：

dystrophin-associated glycoprotein complex; muscular dystrophy; sarcoglycans; zebrafish;

D O I：

10.1016/S0006-291X(03)00355-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The zebrafish is an established model of vertebrate development and is also receiving increasing attention in terms of human disease modelling. In order to provide experimental support to realize this modelling potential, we report here the identification of apparent orthologues of many critical members of the dystrophin-associated glycoprotein complex (DGC) that have been implicated in a diverse range of neuromuscular disorders. In addition, immunohistochemical studies show the localization of the DGC to the sarcolemma of adult zebrafish muscle and in particular the myosepta. Together, these data suggest that the DGC in adult zebrafish may play a highly conserved functional role in muscle architecture that, when disrupted, could offer insight into human neuromuscular disease processes. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：488 / 495

页数：8

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