Differential significance of tumour infiltrating lymphocytes in sporadic mismatch repair deficient versus proficient colorectal cancers:: A potential role for dysregulation of the transforming growth factor-β pathway

被引：58

作者：

Baker, Kristi

Zlobec, Inti

Tornillo, Luigi

Terracciano, Luigi

Jass, Jeremy R.

Lugli, Alessandro

机构：

[1] McGill Univ, Dept Pathol, Montreal, PQ H3A 2B4, Canada

[2] Univ Basel Hosp, Inst Pathol, CH-4031 Basel, Switzerland

来源：

EUROPEAN JOURNAL OF CANCER | 2007年 / 43卷 / 03期

基金：

加拿大健康研究院;

关键词：

colorectal cancer; mismatch repair; tumour infiltrating lymphocytes; intraepithelial lymphocytes; transforming growth factor-beta;

D O I：

10.1016/j.ejca.2006.11.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The prognostic importance of tumour infiltrating lymphocytes (TILs) in colorectal cancer (CRC) remains controversial. The present study was undertaken to evaluate the role of TILs as prognostic indicators and to investigate the role of transforming growth factor-beta (TGF-beta) in TIL infiltration. Immunohistochemical staining for components in the TGF-beta pathway was performed on a tissue microarray of 1420 unselected CRCs with complete clinico-pathological data. Statistical analyses were carried out on samples stratified by mismatch repair (MMR) proficiency status and TIL counts. TIL infiltration was found to correlate with multiple clinico-pathological features but was a prognostic marker only in MMR proficient CRCs. In all CRCs, findings indicative of insensitivity to TGF-beta and increased TGF-beta secretion were independent predictors of high TIL counts, suggesting that perturbations in the TGF-beta signalling pathway play an important role in the recruitment and retention of TILs within CRC epithelium. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：624 / 631

页数：8

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