Localization of CD4 and CCR5 in living cells

被引：43

作者：

Steffens, CM ^{[1
]}

Hope, TJ ^{[1
]}

机构：

[1] Univ Illinois, Coll Med, Dept Microbiol & Immunol MC 790, Chicago, IL 60612 USA

来源：

JOURNAL OF VIROLOGY | 2003年 / 77卷 / 08期

关键词：

D O I：

10.1128/JVI.77.8.4985-4991.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The events preceding human immunodeficiency virus fusion and entry are influenced by the concentration and distribution of receptor and coreceptor molecules on the cell surface. However, the extent to which these proteins colocalize with one another in the cell membrane remains unclear. Using high-resolution deconvolution fluorescent microscopy of living cells, we found that both CD4 and CCR5 accumulate in protruding membrane structures containing actin and ezrin. Although CD4 and CCR5 extensively colocalize in these structures, they do not exist in a stable complex.

引用

页码：4985 / 4991

页数：7

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