Evidence of cross-protection within Leptospira interrogans in an experimental model

被引：112

作者：

Sonrier, C ^{[1
]}

Branger, C ^{[1
]}

Michel, V ^{[1
]}

Ruvoën-Clouet, N ^{[1
]}

Ganière, JP ^{[1
]}

André-Fontaine, G ^{[1
]}

机构：

[1] Ecole Natl Vet Nantes, Unite Bacteriol Med & Mol Leptospires, F-44307 Nantes 03, France

来源：

VACCINE | 2000年 / 19卷 / 01期

关键词：

leptospirosis; vaccination; cross-protection;

D O I：

10.1016/S0264-410X(00)00129-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Killed whole-cell preparations were used as bacterins against leptospirosis. As this type of protection is considered to be serogroup-specific, several serogroups were added to the usual vaccines, and the most pathogenic serovar was chosen for each group. Different leptospire extracts were evaluated for their protective capacity against acute lethal leptospirosis in gerbils (Meriones unguiculatus). Total extracts induced complete protection against homologous challenges and partial protection against heterologous challenges. LPS fractions protected against homologous but not heterologous challenges, whereas protein extract induced significant protection against both types of challenge. Thus, cross-protection within L. interrogans was related to the protein extract. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：86 / 94

页数：9

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