Complicated parapneumonic effusions in children caused by penicillin-nonsusceptible Streptococcus pneumoniae

被引:29
作者
Hardie, WD
Roberts, NE
Reising, SF
Christie, CDC
机构
[1] Childrens Hosp, Med Ctr, Div Pulm Med, Cincinnati, OH 45229 USA
[2] Childrens Hosp, Med Ctr, Div Infect Dis, Cincinnati, OH 45229 USA
关键词
children; parapneumonic effusions; empyema; Streptococcus pneumoniae;
D O I
10.1542/peds.101.3.388
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective. To describe the clinical characteristics of complicated parapneumonic effusions (CPE) in children caused by Streptococcus pneumoniae nonsusceptible to penicillin (PCN-N) and compare their clinical outcome with CPE caused by penicillin-susceptible (PCN-S) organisms. Design. Children with parapneumonic effusions were identified retrospectively between July 1992 and Tune 1996. Charts of patients with CPE were reviewed for data obtained at the time of hospital admission. In addition, outpatient charts and/or the families of children with CPE caused by PCN-N S pneumoniae were reviewed to identify specific risk factors associated with PCN-N organisms. Results. Sixty-four cases of CPE were identified during the 4-year period. In 26 cases a bacterial pathogen was recovered, with S pneumoniae accounting for 23 of these isolates (88%). Of the 23 S pneumoniae cases, 17 were PCN-S and 6 cases were nonsusceptible. Complicated parapneumonic effusions caused by PCN-N S pneumoniae occurred in significantly younger patients than CPE that were PCN-S (2.1 years vs 7.9 years). Nonsusceptible effusions also had a higher incidence of bacteremia than PCN-S effusions (100% vs 29%). There were no significant differences between the two groups for duration of chest tube drainage, febrile days, oxygen use, and hospital stay. Conclusion. CPE caused by PCN-N S pneumoniae is associated with a younger age and higher rate of bacteremia than CPE caused by PCN-S strains. However, there were no significant differences in outcome measures between patients infected with susceptible or nonsusceptible organisms.
引用
收藏
页码:388 / 392
页数:5
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