Heat-shock proteins induce T-cell regulation of chronic inflammation

被引：408

作者：

van Eden, W ^{[1
]}

van der Zee, R ^{[1
]}

Prakken, B ^{[1
]}

机构：

[1] Univ Utrecht, Fac Vet Med, Div Immunol, NL-3584 CL Utrecht, Netherlands

来源：

NATURE REVIEWS IMMUNOLOGY | 2005年 / 5卷 / 04期

关键词：

D O I：

10.1038/nri1593

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune responses to certain heat-shock proteins (HSPs) develop in almost all inflammatory diseases; however, the significance of such responses is only now becoming clear. In experimental disease models, HSPs can prevent or arrest inflammatory damage, and in initial clinical trials in patients with chronic inflammatory disease, HSP-derived peptides have been shown to promote the production of anti-inflammatory cytokines, indicating that HSPs have immunoregulatory potential. In this Review, we discuss the unique characteristics of HSPs that endow them with these immunoregulatory qualities.

引用

页码：318 / 330

页数：13

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