Effects of anesthetics on the function of orexin-1 receptors expressed in Xenopus oocytes

被引：11

作者：

Minami, Kouichiro ^{[1
]}

Uezono, Yasuhito

Sakurai, Takeshi

Horishita, Takafumi

Shiraishi, Munehiro

Ueta, Yoichi

机构：

[1] Jichi Med Univ, Dept Anesthesiol, Shimotsuke Shi, Tochigi 3290483, Japan

[2] Jichi Med Univ, Dept Crit Care Med, Shimotsuke Shi, Tochigi 3290483, Japan

[3] Nagasaki Univ, Grad Sch Med Sci, Dept Pharmacol, Nagasaki 852, Japan

[4] Univ Tsukuba, Grad Sch Comprehens Human Sci, Dept Mol Pharmacol, Tsukuba, Ibaraki 305, Japan

[5] Univ Occupat & Environm Hlth, Sch Med, Dept Anesthesiol, Kitakyushu, Fukuoka 807, Japan

[6] Univ Occupat & Environm Hlth, Sch Med, Dept Physiol, Kitakyushu, Fukuoka 807, Japan

来源：

PHARMACOLOGY | 2007年 / 79卷 / 04期

关键词：

orexin A; orexin-1; receptor; anesthetics;

D O I：

10.1159/000101713

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Neurons in the hypothalamus containing the neuropeptide orexin have been implicated in the control of sleep and wakefulness and in the pathology of narcolepsy. In this study, we investigated the effects of volatile anesthetics, ethanol and intravenous anesthetics on orexin-A-induced Ca2+-activated Cl- currents using Xenopus oocytes expressing orexin- 1 receptors ( OX1Rs). The volatile anesthetics isoflurane, enflurane and halothane inhibited Cl- currents elicited by 1-mu mol/l orexin-A. Ethanol and the intravenous anesthetics pentobarbital and ketamine also inhibited the action of orexin- A. The inhibitory effects of all of the compounds tested were shown to be caused by the inhibition of OX1R function. These results may, at least in part, explain their hypnotic effects. Copyright (c) 2007 S. Karger AG, Basel.

引用

页码：236 / 242

页数：7

共 30 条

[1] Orexin-A, an hypothalamic peptide with analgesic properties [J].

Bingham, S ;

Davey, PT ;

Babbs, AJ ;

Irving, EA ;

Sammons, MJ ;

Wyles, M ;

Jeffrey, P ;

Cutler, L ;

Riba, I ;

Johns, A ;

Porter, RA ;

Upton, N ;

Hunter, AJ ;

Parsons, AA .

PAIN, 2001, 92 (1-2) :81-90

[2] Narcolepsy in orexin knockout mice:: Molecular genetics of sleep regulation [J].

Chemelli, RM ;

Willie, JT ;

Sinton, CM ;

Elmquist, JK ;

Scammell, T ;

Lee, C ;

Richardson, JA ;

Williams, SC ;

Xiong, YM ;

Kisanuki, Y ;

Fitch, TE ;

Nakazato, M ;

Hammer, RE ;

Saper, CB ;

Yanagisawa, M .

CELL, 1999, 98 (04) :437-451

[3] Actions of long chain alcohols on GABA(A) and glutamate receptors: Relation to in vivo effects [J].

DildyMayfield, JE ;

Mihic, SJ ;

Liu, Y ;

Deitrich, RA ;

Harris, RA .

BRITISH JOURNAL OF PHARMACOLOGY, 1996, 118 (02) :378-384

[4] MOLECULAR AND CELLULAR MECHANISMS OF GENERAL-ANESTHESIA [J].

FRANKS, NP ;

LIEB, WR .

NATURE, 1994, 367 (6464) :607-614

[5] SELECTIVE ACTIONS OF VOLATILE GENERAL-ANESTHETICS AT MOLECULAR AND CELLULAR-LEVELS [J].

FRANKS, NP ;

LIEB, WR .

BRITISH JOURNAL OF ANAESTHESIA, 1993, 71 (01) :65-76

[6] ACTIONS OF ANESTHETICS ON LIGAND-GATED ION CHANNELS - ROLE OF RECEPTOR SUBUNIT COMPOSITION [J].

HARRIS, RA ;

MIHIC, SJ ;

DILDYMAYFIELD, JE ;

MACHU, TK .

FASEB JOURNAL, 1995, 9 (14) :1454-1462

[7] Gene expression and protein distribution of the orexin-1 receptor in the rat brain and spinal cord [J].

Hervieu, GJ ;

Cluderay, JE ;

Harrison, DC ;

Roberts, JC ;

Leslie, RA .

NEUROSCIENCE, 2001, 103 (03) :777-797

[8] High specificity of human orexin receptors for orexins over neuropeptide Y and other neuropeptides [J].

Holmqvist, T ;

Åkerman, KEO ;

Kukkonen, JP .

NEUROSCIENCE LETTERS, 2001, 305 (03) :177-180

[9] KETAMINE INFUSIONS - PHARMACOKINETICS AND CLINICAL EFFECTS [J].

IDVALL, J ;

AHLGREN, I ;

ARONSEN, KF ;

STENBERG, P .

BRITISH JOURNAL OF ANAESTHESIA, 1979, 51 (12) :1167-1173

[10] Orexinergic neurons and barbiturate anesthesia [J].

Kushikata, T ;

Hirota, K ;

Yoshida, H ;

Kudo, M ;

Lambert, DG ;

Smart, D ;

Jerman, JC ;

Matsuki, A .

NEUROSCIENCE, 2003, 121 (04) :855-863

← 1 2 3 →