Diterpenoids with inhibitory activity against NFAT transcription factor from Acanthopanax koreanum

被引：5

作者：

Cai, XF ^{[1
]}

Lee, IS ^{[1
]}

Dat, NT ^{[1
]}

Shen, GH ^{[1
]}

Kim, YH ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

来源：

PHYTOTHERAPY RESEARCH | 2004年 / 18卷 / 08期

关键词：

Acanthopanax koreanum; Araliaceae; diterpenoids; NFAT(TF) inhibitor;

D O I：

10.1002/ptr.1523

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Six diterpenoids and two diterpene glycosides were isolated from the dichloromethane and the water fractions of A canthopanax koreanum roots, respectively. Of these compounds, 16alphaH, 17-isovaleryloxy-ent-kauran-19-oic acid containing an isovaleryloxy group at C-17 was found to exhibit the strongest inhibitory activity (IC50 6.7 muM) against NFAT transcription factor. However, sumogaside, 16alpha-hydroxy-ent-kauran-19-oic acid and paniculosides IV containing a hydroxy group at C-16 or a glycoside at C-4 carboxyl acid showed no activity. Copyright (C) 2004 John Wiley Sons, Ltd.

引用

页码：677 / 680

页数：4

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