Regulation of leukocyte recruitment by the long pentraxin PTX3

被引：378

作者：

Deban, Livija ^{[1
]}

Russo, Remo Castro ^{[1
,2
]}

Sironi, Marina ^{[1
]}

Moalli, Federica ^{[1
]}

Scanziani, Margherita ^{[4
]}

Zambelli, Vanessa ^{[3
,4
]}

Cuccovillo, Ivan ^{[1
]}

Bastone, Antonio ^{[3
]}

Gobbi, Marco ^{[3
]}

Valentino, Sonia ^{[1
]}

Doni, Andrea ^{[1
]}

Garlanda, Cecilia ^{[1
]}

Danese, Silvio ^{[1
]}

Salvatori, Giovanni ^{[5
]}

Sassano, Marica ^{[6
]}

Evangelista, Virgilio ^{[7
]}

Rossi, Barbara ^{[8
]}

Zenaro, Elena ^{[8
]}

Constantin, Gabriela ^{[8
]}

Laudanna, Carlo ^{[8
]}

Bottazzi, Barbara ^{[1
]}

Mantovani, Alberto ^{[1
,9
]}

机构：

[1] Ist Clin Humanitas, Inst Ricovero & Cura Carattere Sci, Lab Immunol & Inflammat, Rozzano, Italy

[2] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, Lab Imunofarmacol, Belo Horizonte, MG, Brazil

[3] Mario Negri Inst Pharmacol Res, Milan, Italy

[4] Univ Milano Bicocca, Dept Expt Med, Milan, Italy

[5] Sigma Tau Res & Dev, Pomezia, Italy

[6] Tecnogen, Ric & Sviluppo, Piana Monte Verna, Italy

[7] Ist Ric Farmacol Mario Negri, Consorzio Mario Negri Sud, I-66030 Santa Maria Imbaro, Italy

[8] Univ Verona, Dept Pathol, I-37100 Verona, Italy

[9] Univ Milan, Dipartimento Med Traslaz, Milan, Italy

来源：

NATURE IMMUNOLOGY | 2010年 / 11卷 / 04期

关键词：

C-REACTIVE PROTEIN; SELECTIN GLYCOPROTEIN LIGAND-1; HUMORAL INNATE IMMUNITY; AMYLOID-P COMPONENT; COMPLEMENT; ADHESION; RECOGNITION; MECHANISMS; INFECTION; BINDING;

D O I：

10.1038/ni.1854

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Pentraxins are a superfamily of conserved proteins involved in the acute-phase response and innate immunity. Pentraxin 3 (PTX3), a prototypical member of the long pentraxin subfamily, is a key component of the humoral arm of innate immunity that is essential for resistance to certain pathogens. A regulatory role for pentraxins in inflammation has long been recognized, but the underlying mechanisms remain unclear. Here we report that PTX3 bound P-selectin and attenuated neutrophil recruitment at sites of inflammation. PTX3 released from activated leukocytes functioned locally to dampen neutrophil recruitment and regulate inflammation. Antibodies have glycosylation-dependent regulatory effect on inflammation. Therefore, PTX3, which is an essential component of humoral innate immunity, and immunoglobulins share functional outputs, including complement activation, opsonization and, as shown here, glycosylation-dependent regulation of inflammation.

引用

页码：328 / U74

页数：9

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