Warthin tumor - A new hypothesis concerning its development

Objective. Warthin tumor is the second most common benign parenchymal salivary neoplasm. The purpose of this study was to evaluate the histopathologic features of Warthin tumor to determine whether a developmental pattern could be identified. Study design, Seventy-nine Warthin tumors in 63 patients (62 male and 1 female, average age, 58.62 years) were examined. All cases were histopathologically classified and morphometrically analyzed with an Optomax st stem to measure the proportions of lymphoid tissue and cystic cavities. Results, The predominantly epithelial type (21% of all cases) of Warthin tumor was associated with a mean patient age at diagnosis of 53 years, a mean evolution time of 2.8 months, an average size of 1 cm, and a mean lymphoid component of 10%. In the case of the classical type (61% of all cases), the mean patient age at diagnosis was 58 yeats, the mean evolution time 9 months, the average size 2.4 cm, and the mean lymphoid component 40%. For the predominantly lymphoid type (18% of all cases), these values were, respectively, 62 years, 11 months, 2.8 cm, and 74%. The mean size of the classical and lymphoid tumors (79% of the Warthin tumors) was significantly greater (p < 0.0001) than the mean size of the epithelial type (79% of the Warthin tumors), A positive correlation between tumor size and evolution time was found. Conclusion, Our results suggest that the Warthin tumor initially develops as an adenomatous epithelial proliferation followed by lymphocytic infiltration.