Evaluation of cisplatin and cyclosporin A in recurrent platinum-resistant ovarian cancer: A phase II study of the gynecologic oncology group

Objective. The objective of this study was to study the effectiveness of cyclosporin A and cisplatin in patients with recurrent epithelial ovarian cancer. Methods. Twenty-six patients with measurable recurrent epithelial ovarian cancer, considered to be resistant to cisplatin, received cisplatin in combination with cyclosporin A, Patients received 75 mg/m(2) cisplatin every 3 weeks and two cyclosporin A injections over 2 h each, 24 h apart, at a dose of 4 mg/kg each. Results. Only a single patient had a complete response, with two experiencing a partial response to cyclosporin A/cisplatin combination, Hematologic toxicity in this study was modest, No patient developed grade 4 renal toxicity. Conclusion. These data indicate minimal activity of the combination of cyclosporin A and cisplatin in ovarian cancer patients with recurrent measurable disease previously treated with cisplatin and thought to be resistant to this chemotherapeutic agent. (C) 1998 Academic Press.