Proteomic analysis of bone cancer: a review of current and future developments

被引：15

作者：

Bhattacharyya, Sudeepa

Byrum, Stephanie

Siegel, Eric R.

Suva, Larry J. ^{[1
]}

机构：

[1] Univ Arkansas Med Sci, Barton Res Inst, Ctr Orthopaed Surg, Dept Orthopaed Surg, Little Rock, AR 72205 USA

[2] Univ Arkansas Med Sci, Barton Res Inst, Ctr Orthopaed Res, Dept Biostat, Little Rock, AR 72205 USA

来源：

EXPERT REVIEW OF PROTEOMICS | 2007年 / 4卷 / 03期

关键词：

biomarker; data analysis; expression profiling; osteolysis; metastasis; SELDI-TOF-MS; skeletal malignancy; tandem mass spectrometry;

D O I：

10.1586/14789450.4.3.371

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The ability of sophisticated proteomic approaches to scrutinize the dynamic nature of protein expression, cellular and subcellular protein distribution, post-translational modifications, and protein-protein interactions has culminated in the identification of many potential new therapeutic targets and an abundance of cancer-related biomarkers. From a proteomics perspective, amongst the most under-studied diseases are bone cancers, such as myeloma, osteosarcoma and breast and prostate cancer bony metastases. This review focuses on the recent advances in proteomic technology that have thrust the skeletal cancer field into this exciting age of proteomics, and highlights the future work that is required to adapt this technology to specifically interrogate the skeletal consequences of malignancy.

引用

页码：371 / 378

页数：8

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