The glideosome: a molecular machine powering motility and host-cell invasion by apicomplexa

被引:174
作者
Keeley, A
Soldati, D
机构
[1] Univ London Imperial Coll Sci & Technol, Dept Biol Sci, London SW7 2AZ, England
[2] Univ Geneva, CMU, Fac Med, Dept Genet & Microbiol, CH-1211 Geneva 4, Switzerland
关键词
D O I
10.1016/j.tcb.2004.08.002
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The apicomplexans are obligate intracellular protozoan parasites that rely on gliding motility for their migration across biological barriers and for host-cell invasion and egress. This unusual form of substrate-dependent motility is powered by the 'glideosome', a macromolecular complex consisting of adhesive proteins that are released apically and translocated to the posterior pole of the parasite by the action of an actomyosin system anchored in the inner membrane complex of the parasite. Recent studies have revealed new insights into the composition and biogenesis of Toxoplasma gondii myosin-A motor complex and have identified an exciting set of small molecules that can interfere with different aspects of glideosome function.
引用
收藏
页码:528 / 532
页数:5
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