Synthesis and characterization of amphiphilic poly(ethylene glycol) graft copolymers and their potential application as drug carriers

被引：82

作者：

Chiu, HC

Chern, CS ^{[1
]}

Lee, CK

Chang, HF

机构：

[1] Natl Taiwan Inst Technol, Dept Chem Engn, Taipei 10772, Taiwan

[2] Natl Chung Hsing Univ, Dept Chem Engn, Taichung 40227, Taiwan

来源：

POLYMER | 1998年 / 39卷 / 8-9期

关键词：

amphiphilic copolymers; micelles; poly(ethylene glycol);

D O I：

10.1016/S0032-3861(97)00436-9

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Amphiphilic graft copolymers comprising monomeric units of stearyl methacrylate, methyl acrylate, acrylic acid and poly(ethylene glycol) acrylate were synthesized and their properties in aqueous systems characterized. The structures of these copolymers were analysed by Fourier transform infra-red and nuclear magnetic resonance spectroscopies while their molecular weights were estimated by static light scattering. The study of critical micelle concentrations and micellar sizes indicated that the formation of micelles is primarily determined by the hydrophobic/hydrophilic properties of these copolymers. Encapsulation of pyrene (as a drug model) into the micelles was found to be dependent on their stearyl methacrylate content. These copolymers also exhibited a sustained release pattern for pyrene in aqueous solutions and might indicate their future applications as potential drug delivery systems. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：1609 / 1616

页数：8

共 37 条

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