Trypanocidal effects of gallic acid and related compounds

被引：90

作者：

Koide, T

Nose, M

Inoue, M

Ogihara, Y

Yabu, Y

Ohta, N

机构：

[1] Nagoya City Univ, Fac Pharmaceut Sci, Dept Pharmacognosy & Plant Chem, Mizuho Ku, Nagoya, Aichi 467, Japan

[2] Nagoya City Univ, Sch Med, Dept Med Zool, Nagoya, Aichi 467, Japan

来源：

PLANTA MEDICA | 1998年 / 64卷 / 01期

关键词：

gallic acid; Trypanosoma brucei brucei; trypanocidal activity; bloodstream forms; procyclic forms;

D O I：

10.1055/s-2006-957360

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Gallic acid (3,4,5-trihydroxybenzoic acid) is a naturally abundant plant phenolic compound and it is well known as a component of hydrolyzable tannins. We report here that gallic acid and related compounds have trypanocidal activity against Trypanosoma brucei brucei (GUTat 3.1) in both the long slender bloodstream forms and the procyclic forms, in vitro. LD50 values of gallic acid are 46.96 +/- 1.28 mu M for bloodstream forms and 30.02 +/- 3.49 for procyclic forms, respectively. A study of structurally related compounds suggested that the pyrogallol moiety could be responsible for this activity.

引用

页码：27 / 30

页数：4

共 14 条

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BRUN R, 1979, ACTA TROP, V36, P289

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A COLORIMETRIC ASSAY FOR TRYPANOSOME VIABILITY AND METABOLIC FUNCTION [J].