Opposing actions of BMP3 and TGFβ1 in human bone stromal cell growth and differentiation

被引：25

作者：

Faucheux, C

Ulysse, F

Bareille, R

Reddi, AH

Amédée, J

机构：

[1] Univ Bordeaux 2, INSERM, U443, F-33076 Bordeaux, France

[2] Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 241卷 / 03期

关键词：

D O I：

10.1006/bbrc.1997.7792

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

BMP3 and TGF beta 1 were found to induce opposite effects on human bone marrow stromal cells both in cell proliferation and cell differentiation and on calcium deposition onto the extracellular matrix. Moreover, BMP3 may exert, in part, the inhibitory effect of TGF beta 1 through decreasing the affinity of TGF-beta for its receptors which are now identified in these human bone cells. (C) 1997 Academic Press.

引用

页码：787 / 793

页数：7

共 40 条

[1]

AMEDEE J, 1994, DIFFERENTIATION, V58, P157

[2] INITIATION AND PROGRESSION OF MINERALIZATION OF BONE NODULES FORMED INVITRO - THE ROLE OF ALKALINE-PHOSPHATASE AND ORGANIC PHOSPHATE [J].